The Nanticoke Heritage Byway weaves through Sussex County Delaware with the pristine Nanticoke River as its primary physical feature. The Byway corridor extends from Hearns Pond in the north to Trap Pond State Park in the south. Along their journey, visitors to the Byway will find history and natural beauty in historic Delaware cities and towns, such as Laurel, Bethel, Concord and Seaford.
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| Attraction | Distance from Nanticoke Heritage Byway |
| Baltimore, Maryland | 103 miles |
| Cape May, New Jersey | 53 miles |
| Georgetown, Delaware | 14 miles |
| Lewes, Delaware | 29 miles |
| Newark, Delaware | 90 miles |
| New York City, New York | 208 miles |
| Norfolk, Virginia | 149 miles |
| Ocean City, Maryland | 40 miles |
| Philadelphia, Pennsylvania | 123 miles |
| Rehoboth Beach, Delaware | 33 miles |
| Salisbury, Maryland | 15 miles |
| Washington DC | 105 miles |
| Wilmington, Delaware | 94 miles |